(Roughly) Daily

Posts Tagged ‘philosophy of science

“Reality is a very subjective affair”*…

As Nathan Gardels reports, the Berggruen Institute recently gathered religious scholars, philosophers, quantum physicists, AI technologists, neuroscientists and science fiction novelists at Casa dei Tre Oci in Venice to ponder the nature of consciousness. Noting that “it is fascinating to see how their ideas correspond to the long-ago musings of Medieval mystics and even the “pagan masters” of antiquity'” Gardels observes that “the great question then, as now, and probably forever, is whether there is a metaphysical gap between the body and the soul, or if they are made of the same substance, symbiotic aspects of a singular reality that entail each other.” He concludes…

…The quantum physicist Carlo Rovelli argues that the much-discussed metaphysical gap between body and soul, subjective and objective, doesn’t exist. 

As he has written in Noema, “We, subjects of knowledge and understanding, are not outside the world. We are part of it. Our theories and knowledge are embodied tools to help us navigate the real world, not disembodied views on reality from the outside. They are themselves aspects of the very world they describe. Our understanding, like our feelings, perceptions and experience, is a natural phenomenon.”

For Rovelli, the notion of a metaphysical gap “contradicts everything we have learned about nature in the last centuries. The mind is the behavior of the brain, properly described in a high-level language. Neither my own experience of myself nor an external experience of me is primary: They are two distinct perspectives on the same events. We do not need to assume that the circle between epistemology (how we get knowledge) and ontology (what exists) requires a starting point. There is nothing wrong with its circularity: The world I access is the information I have about it, and I am part of that world.

“Nor do we need to require that there is any ultimate or fundamental account of reality. Any account is approximate, has blind spots and is realized within reality, so it is embodied in a part of that same reality. 

“If we do not fall into the error of dualism upfront, we can safely speak of soul and emotions just as we speak of a kitchen table, even if the table is also a collection of atoms. It is time to give up the pernicious dualism introduced by the debate on consciousness and embrace the reality that our soul, or our spiritual life, is consistent with our fundamental physics. 

“Earth is not metaphysically different from the heavens, living beings are not metaphysically different from inanimate matter, humans are not metaphysically different from other animals. The soul is not metaphysically different from the body. We are all parts of nature.” 

Rovelli’s scientific case that we humans are not outside the world of reality, but constitutive participants in it and constructors of it, tracks with the intuition of Medieval thinkers like the 14th-century Christian mystic Meister Eckhart. 

For Eckhart, consciousness was being aware we are not apart from, but both inhabit and are inhabited by, the mind of God — that is, “objective reality.” 

As stated in the New Testament’s Gospel of John, “In the beginning was the Word, and the Word was with God.” In biblical terms, the Word, or Logos, is divine reason. Eckhart interpreted this passage as meaning that the incarnation of the divine in man was not a one-time event of Christ’s birth in Bethlehem, but takes place through continuous human participation in the unfolding Logos of the Word, making us part of and conjoining with the mind of God; co-essences, so to speak.” If God is the pure thought of divine reason, then, as Sloterdijk has put it, ‘To think is to give birth to God.’”

That Medieval insight is another way of saying, in Rovelli’s words, that “objectivity without a subject is an abstract construct, of little relevance — it is the illusion of a science now belonging to the past.”

Consciousness, then, can be said to be the perspective of the aware self in a world where there is no outside. The “I” is not detached from some order of objective reality, but in all the diversity of personal experience, part of what makes it “everywhere whole.” Not only is “the universe disclosed by a knowing subject;” the knowing subject is its co-creator from within…

Eminently worth reading in full.

Striving to understand the nature of consciousness: “Subjective Perspective Makes Objective Reality ‘Everywhere Whole’,” from @noemamag.com.

Pair with: “Everything is not itself.”

* Vladimir Nabokov, Pale Fire

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As we muse on our minds, we might spare a thought for a man who wrestled with these same issues, Auguste Comte; he died on this date in 1857. A philosopher (and mathematician), he is remembered as the father of the doctrine of positivism. He developed the Law of Three Stages to describe the historical evolution of human thought and consciousness, arguing that the human mind, in its search for understanding, progresses through three distinct intellectual phases (the theological, the metaphysical, and the positive (or scientific), each with a different method of explaining reality.

Comte is widely regarded as the first “philosopher of science” in the modern sense, and as the forebearer of sociology (the name of which he coined, as he did the word “altruism”). He had a major impact on 19th-century thought, influencing the work of social thinkers like John Stuart Mill and George Eliot.  His concepts of “sociology” and social evolutionism set the tone for early social theorists and anthropologists including Harriet Martineau and Herbert Spencer, evolving into modern academic sociology (a la Émile Durkheim) as practical and objective social research.

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Written by (Roughly) Daily

September 5, 2026 at 1:00 am

“Historical oblivion is the default, not the exception”*…

Indeed. And that’s especially true of the institutions that guard the archives that are our cultural heritage. The ongoing transition from physical media sales to digital licensing markets has unleashed a new wave of archival ephemerality, which endangers these memory institutions’ core operations and threatens to plunge society into a digital dark age.

The stakes are high. As Haruki Murakami observed: “Robbing people of their actual history is the same as robbing them of part of themselves. It’s a crime… If our collective memory is taken from us – is rewritten – we lose the ability to sustain our true selves.”

Michael Menna (a Stanford Law Fellow who co-authored the “Our Future Memory” manifesto) and Lila Bailey (Senior Policy Counsel at one of the world’s most crucial repositories, The Internet Archive), call for four digital rights that would allow libraries, archives, museums, and other cultural heritage organizations (“memory institutions”) to uphold their shared public service mission of preserving history and providing access to information…

… We are living through a troubling paradox: Digital technologies have enabled the production and distribution of more information than ever, yet access to that information isincreasingly fragmented and fragile. These technologies should permit us to engage and learn from all the digital content at our fingertips. Instead, many of the basic rights we grew accustomed to in the physical world are now being overtaken by aggressive market tactics that do not reflect the public-interest values the law was meant to protect. If copyright, privacy, and other regulatory frameworks were designed to balance the interests of creators and users with the public’s need to access and contribute to the wealth of human knowledge, then our increasingly digital information economy has thrown that balance out of whack.


In this new media environment, publishers and other content providers have unprecedented power to control knowledge and culture with technical restrictions and exclusionary licensing terms. Governments also have an easier time censoring what people can see by scrubbing their websites and pressuring commercial platforms to do the same. These sudden changes will feel familiar to anyone who has logged onto a streaming service or social media app to find a movie or news story suddenly missing. But for libraries, archives, museums, and other cultural heritage organizations (“memory institutions”), it poses an existential risk to
their core public service mission of preserving culture and protecting history. When these organizations can no longer collect and provide access to digital materials, members of the public cannot place their trust in a stable record—which affects their ability to confidently participate in democratic discourse.


We write this paper from our perspective at the Internet Archive, a nonprofit research library that specializes in web archiving, digitization, and the preservation of media in all forms. We feel the harms from these shifts firsthand and hear many of the same complaints from our partner memory institutions around the world. That shared frustration with today’s digital landscape has given rise to an emerging consensus among libraries, archives, museums, and their allies, calling for better legal protections and practical options to continue their services and preserve cultural memory in today’s information age.


This two-part paper (1) presents the looming threat of “vanishing culture” as a first-order political crisis, and (2) discusses the key role that libraries and other memory institutions can play in meeting that crisis.2 In the first part, we examine the underlying causes of vanishing culture and trace its ripple effects along several different facets of modern life: (a) educational resources, (b) journalistic integrity, (c) civic engagement, (d) religious study, and (e) environmental policy. In the second part, we reintroduce a framework of four rights that would ensure memory institutions’ ability to work together to collect, preserve, and provide access to digital materials. This framework rests on the simple proposition that memory institutions should be allowed to do the same things in the digital world that they’ve historically done in the physical world. It originated in the 2024 statement titled Four Digital Rights for Protecting Memory Institutions Online3 before it became a global rallying cry for the Our Future Memory movement and its growing list of library, archive, and museum signatories. Together, these memory institutions are striving to combat the political causes and effects of vanishing culture by speaking with one voice to the importance of memory work in an age of digital ephemerality. That is why we call on all memory institutions, large and small, to sign onto the Statement and join the movement. Individuals and communities need memory institutions to educate themselves and freely participate in civic life, and every time a content provider lets critical information disappear online, it offers further proof that today’s digital markets alone do not constitute a viable alternative. If things do not change soon, we risk sleepwalking into a future where both memory institutions and the public they serve will become passive consumers, rather than active stewards of human knowledge…

Menna and Bailey explain the situation; unpack the four rights they propose: collection, preservation, access, and collaboration; then issue a call to action.

Eminently worth reading in full: “The Political Threats of Vanishing Culture and the Need to Protect Our Future Memory” (PDF here)

See also Vanishing Culture (full PDF here)

And consider joining me in supporting the Internet Archive.

Jordan Mechner

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As we preserve and share, we might send open birthday greetings to a man who would surely have understood the importance of Menna’s and Bailey’s arguments: Sir Karl Raimund Popper; he was born on this date in 1902.  One of the greatest philosophers of science of the 20th century, Popper is best known for his rejection of the classical inductivist views on the scientific method, in favor of empirical falsification: a theory in the empirical sciences can never be proven, but it can be falsified, meaning that it can and should be scrutinized by decisive experiments.  (Or more simply put, whereas classical inductive approaches considered hypotheses false until proven true, Popper reversed the logic: conclusions drawn from an empirical finding are true until proven false.)

Popper was also a powerful critic of historicism in political thought, and (in books like The Open Society and Its Enemies and The Poverty of Historicism) an enemy of authoritarianism and totalitarianism (in which role he was a mentor to George Soros).

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Written by (Roughly) Daily

July 28, 2026 at 1:00 am

“The first principle is that you must not fool yourself – and you are the easiest person to fool”*…

Close-up of multiple petri dishes filled with reddish liquid, reflecting a scientist's face. The background is softly blurred, emphasizing the petri dishes.

We live in a time when a growing number of “authorities” in the U.S. and around the world are actively trading fact for convenient fiction. Science is under attack; there’s (all-too-grounded) concern that we may be headed into a new “Dark Age.”

C. Brandon Ogbunu pushes back, arguing that science– and more particularly, the emerging research field of metascience, a form of scientific self-examination– is essential for navigating our uncertain future…

On May 24, Vice President J.D. Vance authored a post on X that highlighted a “reproducibility crisis” in the sciences. Vance offered this amid a series of other critiques of higher education to justify the withholding of federal science funding to universities over the past several months. His post was timed to accompany a White House executive order that invoked the language of open science to introduce sweeping changes to our federal scientific infrastructure. It came just weeks after the release of plans to cut science funding in the 2026 fiscal year budget.

The playbook is standard: Fuse an aggressive political agenda to a more palatable set of criticisms. In this case, many agree that processes within professional science have, for decades, had significant flaws. In my view, politicians in power are using this as a justification to burn it down. And outside of a few higher-education legal efforts to fight back, the scientific community remains shell-shocked, unable to gather the momentum to resist effectively.

But in addition to resisting the changes, there might be other ways that we can navigate an uncertain future. In recent years, a field called “metascience” (often referred to as “the science of science”) has emerged, charged with understanding the processes of science, how it operates, and identifying themes in what is produced. I argue that this area is going to be essential moving forward in stormy times, as it can dispel the myth that science is an ideological leviathan incapable of self-reflection and can help us rebuild science into a craft that interrogates its fragilities.

As described in a 2018 review, the science of science “is based on a transdisciplinary approach that uses large data sets to study the mechanisms underlying the doing of science—from the choice of a research problem to career trajectories and progress within a field.” It asks questions about aspects of the scientific enterprise, including employment, publishing trends, economic incentives, merit, and other forces that influence science in ways that may escape our intuition…

[Ogbunu explains metascience, and explores examples of work-to-date and questions like: Who is doing science? What are their incentives (and how do they shape behavior)? How innovative is science? He reminds us that “metascientists” are following in the footsteps of humanists and social scientists (Bruno Latour, for example) have examined science practice for many decades…]

… metascience offers a lens that is especially important at this critical moment. Support for science in the face of attacks is critical and necessary. But ironically, one of the best ways to defend the craft might be for scientists to identify the fragilities before the enemy does. We can use data and models, not solely our op-ed voices and social media timelines (though all can be useful). The field is already disabusing us of the notion that science as practiced is based on defensible incentives, neutrality of any kind, or merit, however defined.

Instead, it operates on what looks more like a runaway Matthew Effect, whereby the most established scientists benefit disproportionately from the system of reward — and thus the rich get richer. And the problem isn’t that the flaws exist, but that science’s practitioners aren’t interested in a critical lens towards them.

Metascience won’t fix our problems, but it formalizes ways that we can use to reflect, which may implore us to change science for the better…

Physicians (and other scientists) healing themselves: “Metascience Is More Important Now Than Ever,” from @cbo.bsky.social in @undark.org.

Richard Feynman

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As we commit to comprehension, we might send insightful birthday greetings to a forefather of metascience, Charles Sanders Peirce; he was born on this date in 1839. A scientist, mathematician, logician, and philosopher, he was (per philosopher Paul Weiss) “the most original and versatile of America’s philosophers and America’s greatest logician”. Bertrand Russell wrote “he was one of the most original minds of the later nineteenth century and certainly the greatest American thinker ever.” He is considered by many to be “the father of pragmatism“; he helped formalize the field of statistics; and his contributions logic were foundational– helping to found semiotics (the study of signs).

For Peirce, logic encompassed much of what is now called epistemology and the philosophy of science. Peirce approached science as a practice, defining the concept of abductive reasoning to explain scientific advance, as well as rigorously formulating mathematical induction and deductive reasoning.

Black and white portrait of Charles Sanders Peirce, featuring a man with a prominent beard, wearing a dark suit and patterned tie, with a serious expression.

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“Brains exist because the distribution of resources necessary for survival and the hazards that threaten survival vary in space and time”*…

And, it seems, they not only evolve, but in ways and with a frequency we’ve only just begun to appreciate. It’s long been noted that evolution seems to have a thing for “carcinization”– crabs have evolved separately at least five times. (Oh, and apparently also for anteaters…) Recent findings hint that evolution might have the same sort of jones for the brain. Amy Maxmen reports…

Our brains, perched atop a network of nerve cells that ascend the length of our bodies, are thought to have arisen once in an animal hundreds of millions of years ago and then evolved over time. However, new findings suggest instead that brains and nervous systems originated multiple times from scratch.

The findings, published today in Nature, highlight an ancient and gelatinous marine predator called a comb jelly [pictured at top]. Unlike pulsating jellyfish, comb jellies swim by “rowing” their many hair-like cilia, which are arranged in rows called combs. They possess rudimentary brains and sophisticated nervous systems replete with elongated cells that communicate through synapses much like our own. Some comb jellies show mirror-like bilateral symmetry, as do we. And like most animals, their muscles derive from a middle tissue layer, which does not exist in jellyfish or sponges, another ancient type of aquatic creature. 

So it’s little wonder that biologists have long placed the comb jelly group close to worms, flies, and humans on the evolutionary tree of life; sponges emerge at the base, meaning that this group appeared first. In this traditional view, complex body parts like the brain and muscles arose gradually, and only once, since those parts look similar across related animals, and the chances of that same evolutionary process being repeated seems slim.

But this scenario was shaken by a report in Science last year, which suggested that the comb jelly group emerged before jellyfish and even the brainless, muscle-less sponges, more than 550 million years ago.

Some biologists doubted the rearrangement because it implied two equally uncomfortable possibilities: that the ancestor of all living animals had true muscles and a rudimentary brain, and then sponges and jellyfish lost those parts without a trace; or that the great animal ancestor was simple, and comb jellies evolved separately from all the other animals, yet ended up with rather similar nervous systems, muscles, and bilateral symmetry. When paleontologist Graham Budd heard the news last year, he said, “It is effectively saying animals evolved twice. Frankly, I’m not ready to believe it.”  

Without a time machine, it’s impossible to know what our great ancestor looked like. However, today’s report adds more support to the notion that she was simple and comb jellies independently evolved their complex body parts. Leonid Moroz, a neurobiologist at the University of Florida’s Whitney Laboratory for Marine Bioscience, and his colleagues confirm comb jellies’ position below sponges at the base of the evolutionary tree with an analysis of genetic sequences from 11 comb jelly species…

… In an essay for Nautilus called “Evolution, You’re Drunk,” I described how hypotheses entrenched in the notion that evolution leads toward increasing complexity have recently begun to teeter. Now Moroz’s study adds another shove. It seconds the finding that simple sponges, long placed at the base of the evolutionary tree, actually evolved after the sophisticated comb jelly group arose. The story of how complexity evolves is more complex than scientists realized.

Furthermore, the brain—the epitome of complexity—seems to have sprouted up at least twice over evolutionary time. This clashes with the traditional notion that complex, multifaceted features come about in a very specific way, and each emerges just one time. “What everyone has said about complexity is wrong,” Moroz says. “It can happen more than once.” 

Finding that comb jellies independently arrived at similar ends as other animals might also have surprised the late paleontologist Stephen Jay Gould, who famously doubted that animals would look the same today if the world were to begin again—if we could replay “the tape of life.”

Is such convergence in design a coincidence? Probably not, guesses Andreas Hejnol, an evolutionary developmental biologist at the Sars International Centre for Marine Molecular Biology in Norway. “If you need a fast communication system, it helps to have extended cells that communicate through chemicals,” he says. In other words, the structure of the nervous system reflects its function. So if intelligent life exists elsewhere in the universe, it’s not too far a stretch to think it could possess a brain comprised of trillions of neurons. Hejnol asks, “How else could it be?”…

The mysterious mechanism of evolution: “Evolution May Be Drunk, But It’s Serious About Making Brains,” from @amymaxmen.bsky.social‬ in @nautil.us‬.

* John M. Allman, Evolving Brains

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As we contemplate the changing comprehension of cerebra, we might send thoughtful birthday greetings to Sir Karl Raimund Popper; he was born on this date in 1902.  One of the greatest philosophers of science of the 20th century, Popper is best known for his rejection of the classical inductivist views on the scientific method, in favor of empirical falsification: a theory in the empirical sciences can never be proven, but it can be falsified, meaning that it can and should be scrutinized by decisive experiments.  (Or more simply put, whereas classical inductive approaches considered hypotheses false until proven true, Popper reversed the logic: conclusions drawn from an empirical finding are true until proven false.)

Popper was also a powerful critic of historicism in political thought, and (in books like The Open Society and Its Enemies and The Poverty of Historicism) an enemy of authoritarianism and totalitarianism (in which role he was a mentor to George Soros).

A black and white portrait of Sir Karl Raimund Popper, a prominent philosopher of science, displaying a thoughtful expression.

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And sadly: RIP, Tom Lehrer.

Portrait of singer-songwriter Tom Lehrer, during a rare interview at his home near Santa Cruz, California, USA in early 2000. (source)

“The advance of genetic engineering makes it quite conceivable that we will begin to design our own evolutionary progress”*…

Book illustration of a fish with four legs from The Comic History of Rome, published in 1852

The obligations of a multi-day meeting (and the travel involved) mean that, from this issue, (R)D will be on pause until February 12 or 13 (depending on how connections play out…)

… and indeed the evolutionary progress of others species. But, Deputy Co-chair of the Nuffield Council on Bioethics Melanie Challenger asks, have we been sufficiently thoughful about the implications of this power?…

In 2016,  Klaus Schwab announced that we had entered the Fourth Industrial Revolution. This is the era of the industrialization of biology, the leveraging of technologies to modify biological materials to meet human goals. While the first two Industrial Revolutions exploited energy and materials and the Third exploited digital information, the current revolution is a direct manipulation of life-forms and life’s substances.  

The signature invention of this new era is CRISPR, dubbed “genetic scissors.” CRISPR is a ground-breaking method of making precise changes to DNA for a wide range of possible uses from disease reduction and elimination to the eradication of “pest” species and increases in the productivity of farmed animals. CRISPRs (the best-known system being CRISPR-Cas9) originate in RNA-based bacterial defense systems. Naturally occurring in species of bacteria, the Cas9 enzyme cuts the genomes of bacteriophages (viruses that will attack a bacterium), saving a record for defense against future infections. Scientists realized that this immunological strategy could be coopted to innovate a general tool for cutting DNA.  

The optimism among those that seek to utilize these tools has been palpable for some time. As noted by the researchers at The Roslin Institute, creators of Dolly the Sheep, the world’s first cloned mammal: “Until recently, we have only been able to dream of…the ability to induce precise insertions or deletions easily and efficiently in the germline of livestock. With the advent of genome editors this is now possible.” 

But the technologies of this new industrial era present ethical dilemmas and unknown consequences. What will it take to ensure that this revolution avoids worsening the enormous challenges we already face, especially from biodiversity loss and climate change? How can we get the balance right between the benefits and risks of human inventiveness? 

In the 1980s, tech theorist David Collingridge presented his eponymous dilemma for those seeking to control potentially disruptive technologies. First, there is an “information problem” in which significant impacts are often invisible until the technology is already in use. Second, there is a “power problem” in which the technology becomes difficult to shape, regulate or scale back once it has become integrated in our lives. If we are going to navigate the Fourth Industrial Revolution successfully, we need to examine our use of CRISPR through the Collingridge dilemma.  

The investors and engineers of the first industrial revolutions in the nineteenth century provide a vivid example of the information problem. They hoped that innovations like the combustion engine would unlock efficiency across multiple human sectors, from transportation to logistics to tourism. Such optimism was not unwarranted. Yet, as Collingridge’s dilemma suggests, it is easier to picture gains than to predict trouble. Building road systems and infrastructure carved capital movements into the landscape, symbolising freedom and the flow of wealth and creativity. Yet the striking visual parallels with our circulatory system did not stimulate anyone to forecast the ninety per cent of people today who are exposed to unsafe pollution levels from traffic or the associated health burdens from heart and lung disease to asthma. Nobody then foresaw the yearly deaths of two billion or so non-human vertebrates on our roads today, or that high traffic areas would cause localised declines in insect abundance of at least a quarter and, in some studies, as much as eighty per cent.  

And, of course, most calamitous of all, there is climate change. Traffic emissions account for a fifth of all contributions to global warming. Yet the idea that a profitable and efficient machine like the combustion engine might precede devastating shifts in temperature and weather patterns was scarcely conceivable at the time. Now, it is a near ubiquitous feature of our understanding of the world. 

When it comes to the engineering of biology, a similar information problem abounds. Not only is our understanding of biological life incomplete, but we know little about what the industrial processes that we are advancing inside the cells of organisms will do. The changes are both physically and ethically occluded. The ramifications of this and other related biotechnologies are not only rendered uncertain by the inherently complex nature of biological systems but are largely inaccessible to our imaginations.  

We must struggle with the radical character of the industrialization of biology. Gene drives (a tool to increase the likelihood of passing on a gene) can weaponize the bodies and reproductive strategies of organisms to bias evolution in a directed way. Artificial chimeric organisms (those composed of cells from more than one species) mix and match biological traits and functions to bring about beings that wouldn’t occur otherwise, transforming autonomous organisms into useful parts for plug and play. But while evolutionary processes will sift those forms and strategies that most benefit future organisms, our acts of creation primarily benefit us alone. Survival of the fittest gives way to the contrivance of the functional.  

Yet, despite the disruptive nature of these technologies, CRISPR is already entrenched in our research and economic landscape: here is the power problem of our new technology. The efficiency of modern versions of CRISPR has allowed the technology to pick up users fast. It is now a commonplace tool in labs around the world – with uses amplified during the pandemic – and continues to be utilized in ethically provocative trials, including the cloning of mammal species. CRISPR has been normalised by stealth. 

This largely uncontested rollout has been enabled by biases in the evaluation of who is at risk. Put bluntly, humans worry about humans, and take risks to non-humans less seriously. As such, there are vastly different acceptance thresholds for certain kinds of uses and these can be exploited by those that seek to deregulate or profit from the technologies…

… This discrepancy is evident in the anxieties of Jennifer Doudna, one of the Nobel-winning scientists who made the CRISPR breakthrough. In her book, A Crack in Creation, she writes of a dream in which Hitler appears to her with the face of a pig and questions her excitedly about the power she has unleashed. Doudna’s anxieties relate not to the pigs of her dream (who are subject to a wide range of CRISPR applications) but to the potential of eugenics re-emerging in human societies. Her dream reflects not only the inevitability that any technology such as this will be equal parts destruction to rewards, but also that we must confront uncomfortable ideas about what it is to be a creature as much as a creator. Recognizing that these technologies work in the bodies of all biological beings, including humans, is a continual assault on the reasoning behind a hard moral border between us and them.  

At present, the lives of non-human animals are the experimental landscape for our technologies. Their powerlessness to protest the uses of their bodies, wombs, physical materials, or futures leaves them vulnerable to being the test sites for a wide range of possible human applications. As a direct consequence of the serviceability of the bodies of organisms, CRISPR has been integrated into our world with little fanfare, directly facilitating the power problem that will, eventually, impact us too. Given Collingridge’s dilemma, what concepts and strategies could help us reduce the risks from CRISPR?

The first thing we need is a new definition of pollution. When it comes to combustion engines and other technologies of the first industrial revolutions, pollution is by far the most consequential harm. Direct impacts include the release of particulate matter or chemical compounds like nitrogen oxides or carbon dioxide into the atmosphere. Pollution from traffic has an immediate impact, especially fifty to one hundred metres from the roadside, with effects that we can measure, such as reduced growth rates or leaf damage in plants, or changes to soil chemistry and nutrient availability. On the other hand, long term effects of emissions, such as global warming, or the sustained impacts of waste on organisms and ecosystems, have proven tricky to anticipate and even harder to hold in mind…

…What is curious about the Fourth Industrial Revolution is that while several branches of science are arming us with the evidence that justifies an expansion of the moral circle to encompass a larger range of organisms, other branches are cranking up the objectification and exploitation of life-forms. As a result, there’s an obvious gap. Without addressing this, most concepts of pollution will remain anthropocentric. This may prove a critical misstep…

A provocative argument that “Gene Editing is Pollution,” from @TheIdeasLetter. Eminently worth reading in full.

See also: “The Ethics and Security Challenge of Gene Editing” and “The great gene editing debate: can it be safe and ethical?

* Isaac Asimov

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As we ponder permuted progeny, we might send microbiological birthday greetings to Jacques Lucien Monod; he was born on this date in 1910. A biochemist, he shared (with with François Jacob and André Lwoff) the Nobel Prize in Physiology or Medicine in 1965, “for their discoveries concerning genetic control of enzyme and virus synthesis.”

But Monod, who became the director of the Pasteur Institute, also made significant contributions to the philosophy of science– in particular via his 1971 book (based on a series of his lectures) Chance and Necessity, in which he examined the philosophical implications of modern biology. The importance of Monod’s work as a bridge between the chance and necessity of evolution and biochemistry on the one hand, and the human realm of choice and ethics on the other, can be seen in his influence on philosophers, biologists, and computer scientists including Daniel Dennett, Douglas Hofstadter, Marvin Minsky, and Richard Dawkins… and as a context setter for the deliberations suggested above…

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