(Roughly) Daily

Posts Tagged ‘Life

“The only reason for time is so that everything doesn’t happen at once”*…

Our lives are spread across range of ways that we spend our time. A newly-published study tracks time-use around the world…

How do you spend each day? Researchers sought answers to that basic question from people of various ages living around the world. They report that on an average day, people spend more than a third of their time focused on matters of health, happiness and keeping up appearances.

“We found that the single largest chunk of time is really focused on humans ourselves, a little more than 9 hours,” explained study author Eric Galbraith, of McGill University in Montreal, Canada. “Most of this—about 6.5 hours—is doing things that we enjoy, like hanging out, watching TV, socializing and doing sports,” he said. Reading and gaming also fall within this rubric.

The other 2.5 hours (out of the 9) are spent on hygiene, grooming and taking care of our own health and that of our kids, said Galbraith, a professor in the department of earth and planetary sciences.

Sleep and bedrest occupy the next largest chunk of time: more than 9 hours on average. That sounds like a lot of shut-eye, but Galbraith stressed this number reflects the average across the full age span, so it includes kids who might sleep up to 11 hours a day. “It also includes time in bed and not sleeping, which can be as much as one hour per day,” he said…

The remaining minutes? They seem to go toward getting organized, moving about or producing, creating and maintaining things and spaces…

For more findings and background on the methodology: “Sleep, cleaning, fun: Research reveals the average human’s day worldwide,” in @physorg_com.

* Albert Einstein

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As we contemplate chronology, we might recall that it was on this date in 2011 that the Swedish game design house Mojang Studios released the first full version of Minecraft. A sandbox game created  by Markus “Notch” Persson, it has become the best-selling video game in history, with over 300 million copies sold– and countless hours consumed…

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“There are more things in heaven and Earth, Horatio, than are dreamt of in your philosophy”*…

And some of them were recently found in the woods near Boston…

Researchers have unearthed a trove of wonders in the soil of a Massachusetts forest: an assortment of giant viruses unlike anything scientists had ever seen. The find suggests this group of relatively massive parasites has an even greater ecological diversity and evolutionary importance than researchers knew.

Giant viruses can exceed 2 micrometers in diameter, on par with some bacteria. They can also harbor immense genomes, which reach 2.5 megabases—larger than the genomes of far more complex organisms. Between the discovery of these impressively sized viruses in algae and the culturing of amoeba-infecting Mimiviruses, most of the research on the group has focused on viruses that inhabit freshwater environments. But DNA sequencing has long indicated that giant viruses are diverse and abundant elsewhere, too—especially in sediments and soils, which are estimated to host some 97% of all the viral particles on Earth. Indeed, genomic sequencing of the soils of Harvard Forest—a roughly 16-square-kilometer area west of Boston—indicated the presence of numerous, novel giant viruses.

Now, electron microscopy has allowed scientists to see what others had only sequenced. The diversity of forms was astounding, they report in a bioRxiv preprint. Not only did the researchers see the 20-sided icosahedral shapes they expected, they spotted ones with myriad modifications—tails, altered points, and multilayered or channeled structures abounded. There were even viruses with long tubular appendages, which the team dubbed “Gorgon” morphology [photo above]. Furthermore, many of these putative viral particles were coated with almost hairlike projections, which varied in length, thickness, density, and shape.

The findings suggest virologists have much to discover about how giant viruses interact with their host cells. That likely means the ecological roles these viruses play in soils—and elsewhere they’re found—are woefully underappreciated…

Microbes come in a variety of shapes, hinting at undiscovered ecological diversity: “Alien-looking viruses discovered in Massachusetts forest,” in @ScienceMagazine.

* Shakespeare, Hamlet

As we marvel at multifariousness (and note that viruses, while generally considered to be non-living and thus not considered microorganisms, are colloquially lumped in with microbes), we might spare a thought for Sidney Walter Fox; he died on this date in 1998.  A biochemist, he was responsible for a series of discoveries about the origin of life.  Fox believed in the process of abiogenesis, by which life spontaneously organized itself from the colloquially known “primordial soup,” poolings of various simple organic molecules that existed during the time before life on Earth.  In his experiments (which possessed, he believed, conditions like those of primordial Earth), he demonstrated that it is possible to create protein-like structures from inorganic molecules and thermal energy.  Dr. Fox went on to create microspheres that he said closely resembled bacterial cells and concluded that they could be similar to the earliest forms of life or protocells.

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“Nature is full for us of seeming inconsistencies and glad surprises”*…

George Musser talks with biologist Michael Levin about his practice of uncovering the incredible, latent abilities of living things…

Michael Levin, a developmental biologist at Tufts University, has a knack for taking an unassuming organism and showing it’s capable of the darnedest things. He and his team once extracted skin cells from a frog embryo and cultivated them on their own. With no other cell types around, they were not “bullied,” as he put it, into forming skin tissue. Instead, they reassembled into a new organism of sorts, a “xenobot,” a coinage based on the Latin name of the frog species, Xenopus laevis. It zipped around like a paramecium in pond water. Sometimes it swept up loose skin cells and piled them until they formed their own xenobot—a type of self-replication. For Levin, it demonstrated how all living things have latent abilities. Having evolved to do one thing, they might do something completely different under the right circumstances.

Not long ago I met Levin at a workshop on science, technology, and Buddhism in Kathmandu. He hates flying but said this event was worth it. Even without the backdrop of the Himalayas, his scientific talk was one of the most captivating I’ve ever heard. Every slide introduced some bizarre new experiment. Butterflies retain memories from when they were caterpillars, even though their brains turned to mush in the chrysalis. Cut off the head and tail of a planarian, or flatworm, and it can grow two new heads; if you amputate again, the worm will regrow both heads. Levin argues the worm stores the new shape in its body as an electrical pattern. In fact, he thinks electrical signaling is pervasive in nature; it is not limited to neurons. Recently, Levin and colleagues found that some diseases might be cured by retraining the gene and protein networks as one might train a neural network. But when I sat down to talk to the audacious biologist on the hotel patio, I mostly wanted to hear about slime mold…

Read on for a fascinating conversation: “The Biologist Blowing Our Minds,” @drmichaellevin and @gmusser in @NautilusMag.

* Margaret E. Barber

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As we’re amazed, we might send tidy birthday greetings to Irwin Rose; he was born on this date in 1926. A biologist and biochemist, he shared the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

Ubiquitin is a small protein molecule that attaches to other proteins, tagging them for removal, which are thus recognized by the cell’s proteasomes. These structures are the cell’s waste-disposal units, allowing the proteins to be broken down into tiny pieces for reuse; this ubiquitin-mediated process cleans up unwanted proteins resulting during cell division, and performs quality control on newly synthesized proteins… which matters, as faulty protein-breakdown processes lead to such conditions as cystic fibrosis, several neurodegenerative diseases, and certain types of cancer.

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Written by (Roughly) Daily

July 16, 2023 at 1:00 am

“For you formed my inward parts; you knitted me together in my mother’s womb. I praise you, for I am fearfully and wonderfully made.”*…

DNA is indisputably important to biological development. But, Alfonso Martinez Arias argues, far from being a blueprint for an organism, genes are mere tools used by life’s true expert builders: cells…

… Over the past century, scientists have discovered a material explanation for the source of life, one that needs no divine intervention and provides a thread across eons of time for all beings that exist or have ever existed: deoxyribonucleic acid — DNA. While there is little doubt that genes have something to do with what we are and how we come to be, it is difficult to answer precisely the question of what their exact role in all of this is.

A closer look at how genes work and what they can accomplish, compared to what they are said to achieve, casts doubt on the assertion that the genome in particular contains an “operating manual” for us or any other living creature. When it comes to the creation of organisms, we’ve overlooked — or, more accurately, forgotten — another force. The origin and power of that force are cells.

What makes you and me individual human beings is not a unique set of DNA but instead a unique organization of cells and their activities…

A fascinating essay, adapted from Martinez Arias’ forthcoming book, The Master Builder- How the New Science of the Cell Is Rewriting the Story of Life: “Cells, Not DNA, Are The Master Architects Of Life,” in @NoemaMag.

[Image above: source]

* Psalm 139: 13–14

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As we delve into design, we might send insightful birthday greetings to Ernst Mayr; he was born on this date in 1904. A  taxonomist, tropical explorer, ornithologist, philosopher of biology, and historian of science, he is best remembered as one of the 20th century’s leading evolutionary biologists. His work contributed to the conceptual revolution that led to the modern evolutionary synthesis of Mendelian genetics, systematics, and Darwinian evolution, and to the development of the biological species concept.

His theory of peripatric speciation (a more precise form of allopatric speciation which he advanced), based on his work on birds, is still considered a leading mode of speciation, and was the theoretical underpinning for the theory of punctuated equilibrium, proposed by Niles Eldredge and Stephen Jay Gould. Mayr is sometimes credited with inventing modern philosophy of biology, particularly the part related to evolutionary biology, which he distinguished from physics due to evolutionary biology’s introduction of (natural) history into science.

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“Not what we have, but what we enjoy, constitutes our abundance”*…

After Aristotle, Hellenic philosophy was dominated by two rival schools of thought, the Stoic (founded by Zeno) and the Epicurean (founded by Epicurus). Over the centuries since, “stoic” has come to mean “self-disciplined indifference to pleasure or (especially) pain as a matter of principle or self-discipline,” while “epicurean” has now conjures “fond of or adapted to luxury or indulgence in sensual pleasures; having luxurious tastes or habits, esp. in eating and drinking.” But as Emily Austin argues in Living for Pleasure, an Epicurean Guide to Life, that’s a bum rap. Stoicism is having a moment. In a review of her new book, Julian Baggini argues that we should consider Epicureanism as well…

No one today would dream of practising the physics, medicine or biology of the ancient Greeks. But their thoughts on how to live remain perennially inspiring. Plato, Aristotle and the Stoics have all had their 21st-century evangelists. Now it is Epicurus’s turn, and his advocate is American philosopher Emily A. Austin.

Living for Pleasure is likely to evoke feelings of deja vu. One reason why “ancient wisdom” is so enduring is that most thinkers came to very similar conclusions on certain key points. Do not be seduced by the shallow temptations of wealth or glory. Pursue what is of real value to you, not what society tells you is most important. Be the sovereign of your desires, not a slave to them. Do not be scared of death, since only the superstitious fear divine punishment.

The more general such claims are, the easier it is to agree. But when we delve into what makes the various philosophers different, what sounds like universal good sense can suddenly seem a bit wacky.

Epicurus’s distinctive feature is his insistence that pleasure is the source of all happiness and is the only truly good thing. Hence the modern use of “epicurean” to mean gourmand. But Epicurus was no debauched hedonist. He thought the greatest pleasure was ataraxia: a state of tranquility in which we are free from anxiety. This raises the suspicion of false advertising – freedom from anxiety may be nice, but few would say it is positively pleasurable.

Still, in a world where even the possibility of missing out inspires fear, freedom from anxiety sounds pretty attractive. How can we get it? Mainly by satisfying the right desires and ignoring the rest. Epicurus thought that desires could be natural or unnatural, and necessary or unnecessary. Our natural and necessary desires are few: healthy food, shelter, clothes, company. As long as we live in a stable, supportive community, they are easy to achieve…

There’s much more in this timely guide to the Greek philosopher – and rival to the Stoics – who saw freedom from anxiety as the ultimate goal: “Living for Pleasure by Emily A Austin – an Epicurean guide to happiness,” from @JulianBaggini in @guardian.

See also: “How to be an Epicurean.”

* Epicurus

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As we contemplate contentment, we might send revelatory birthday greetings to Emanuel Swedenborg; he was born on this date in 1688 (O.S.). At age 53, after a successful career as an inventor and scientist, Sedenborg began to experience dreams and visions, a “spiritual awakening,” in which he received a revelation that Jesus Christ had appointed him to write The Heavenly Doctrine to reform Christianity. According to The Heavenly Doctrine, the Lord had opened Swedenborg’s spiritual eyes so that from then on, he could freely visit heaven and hell to converse with angels, demons and other spirits, and that the Last Judgment had already occurred in 1757 (not by Christ in person but by a revelation from him through the inner, spiritual sense of the Word through Swedenborg), the year before the 1758 publication of De Nova Hierosolyma et ejus doctrina coelesti (Concerning the New Jerusalem and its Heavenly Doctrine).  The New Church, also known as Swedenborgianism, is a new religious movement originally founded in 1787 and comprising several historically related Christian denominations that revere Swedenborg’s writings as revelation.

Swedenborg argued against Luther’s concept of salvation through faith-alone (sola-fide in Latin), since he considered both faith and charity necessary for salvation. His thinking influenced a variety of important cultural figures, both writers and artists, including Robert Frost, Johnny Appleseed, William Blake, Jorge Luis Borges, Daniel Burnham, Arthur Conan Doyle, Ralph Waldo Emerson, John Flaxman, George Inness, Henry James Sr., Carl Jung, Immanuel Kant, Honoré de Balzac, Helen Keller, Czesław Miłosz, Joseph Smith, August Strindberg, D. T. Suzuki, and W. B. Yeats.

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Written by (Roughly) Daily

January 29, 2023 at 1:00 am

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