Posts Tagged ‘medicine’
“Of all the forms of inequality, injustice in health care is the most shocking and inhuman”*…
Why are health care costs so high in the U.S.? Harvard public health scholar John McDonough chalks it up to a “wrong turn” in 1980, and the consequences that have ensued…
“What happened in 1980?” John McDonough wondered every time he looked at the numbers.
After 1980, U.S. healthcare became far more expensive than care in peer nations such as France and Germany. In 1980, the U.S. was at the top of a tight pack of industrialized democracies. After that, the cost of American healthcare soared. By 2024, U.S. spending as a percentage of GDP was about 50 percent higher than that of peer nations.
“In the early 1980s, we can see a significant upsurge,” McDonough, professor of the practice of public health at the Harvard T.H. Chan School of Public Health, said in an interview. “All of a sudden, we jumped from the rest of the crowd and were now in a category by ourselves. Over the following 40, 45 years, the distance kept growing.”
McDonough knew what he could rule out: Any suggestion that Americans get more for their money. On the contrary, millions of U.S. citizens are uninsured; out-of-pocket costs and medical debt are high; and even people with insurance have trouble getting appointments. Meanwhile, physician satisfaction is low, leading to early retirements and migration to nontraditional models like concierge care.
When the pandemic hit, McDonough had time for a deep dive into the issue. This month, after a five-year “labor of love,” he’s presenting his answer in a new book, America’s Wrong Turn: US Health Care in the Neoliberal Era [here]. In it, McDonough links increases in healthcare costs to a new political and economic era dominated by a belief in an unfettered free market, tax cuts, deregulation, privatization, smaller government, increased immigration, and free trade.
This trend in U.S. policy — “Reaganomics” before it became “neoliberalism” — included tax, spending, and regulatory overhauls instituted during President Ronald Reagan’s eight years in the White House. But McDonough, a Democrat who served 13 years in the Massachusetts House of Representatives, isn’t just interested in Reagan. Over the next 40 years, some presidents adhered to neoliberalism’s tenets but even those who didn’t were influenced by its deep penetration into the nation’s political and economic ecosystem, he says.
McDonough found a guide in the writings of Yale University political scientist Stephen Skowronek, who suggests that presidents should be measured by the durability and influence of their ideas and values well beyond their terms in office. Skowronek identified only five singular and decades-long eras in U.S. history, those of Thomas Jefferson, Andrew Jackson, Abraham Lincoln, Franklin Delano Roosevelt, and Ronald Reagan.
While Reagan was the first president to espouse neoliberal political and economic philosophy, the core ideas date back decades, fostered by Nobel Prize-winning economist Milton Friedman, who became a key economic adviser to Reagan.
“There was a New Deal-FDR era between 1933 and 1980,” McDonough said. “The neoliberal era that Reagan kicked off saw itself as the corrective to the pro-government prior era. Important dynamic consistencies persisted among Ronald Reagan and Bill Clinton, George W. Bush, and even Barack Obama. There were sets of beliefs with a Republican conservative flavor and with a Democratic flavor that were surprisingly consistent.”
When describing the U.S. healthcare system under neoliberalism, McDonough, who worked with U.S. senators on the Affordable Care Act, cites several major effects, chief among them a permissiveness toward corporate mergers and consolidations that reduces competition, and an unleashing of private equity.
Since the 1980s, U.S. healthcare has become increasingly consolidated, dominated by fewer and larger organizations. The two largest dialysis centers have 92 percent of the U.S. market, for example, while the two largest providers of intravenous solutions control 75 percent of the market. The two largest syringe manufacturers have a 69 percent market share.
Consolidation extends to physician and hospital markets, with 90 percent of hospital markets, 65 percent of physician specialist markets, and 74 percent of health insurance markets considered highly concentrated, McDonough writes.
One argument for larger organizations is the potential for cost saving through both efficiencies and a greater ability to negotiate savings, but the cost-saving record of larger organizations in healthcare is poor, McDonough says. He cites a 2022 RAND study that indicates that price increases of between 3 percent and 65 percent accompany hospital mergers.
Private equity’s focus on generating profits to maximize shareholder value conflicts with improving patient care, McDonough argues. When private equity firms target businesses, enhance their operations, and quickly resell them at a profit, critics say the value extraction from the deals creates harmful operating cuts and dismantling rather than business improvement.
McDonough reviews other key forces in the evolution of U.S. healthcare in recent decades, including fragmentation leading to high administrative costs, low spending on public health and preventive care, unequal access and uneven quality of care, and cost shifts onto consumers via copays, coinsurance and other cost-sharing mechanisms, which result in high levels of medical debt.
McDonough offers prescriptions, but recognizes that change will require political buy-in for things such as strengthened antitrust action to break up megacompanies and stronger regulation of prescription drug pricing, both difficult in an era of sharply divided politics. Government, along with industry, needs to reaffirm a commitment to patient care as the center of its efforts, he says, while also foregrounding equity, access, affordability, and population health.
“The damage to U.S. health and medical care from the 40-year neoliberal era has left considerable harm for patients and consumers, for medical workers at all levels, and for public/population health,” McDonough said. “It will take radical action to reinvigorate the values and principles of our health system that have been lost and eroded. An essential way to do this is to understand how we got to this position in the first place.”…
How we got here and how to respond: “How to fix U.S. healthcare? ‘Radical action’,” from @harvardmagazine.bsky.social.
For a case in point, see David Oks‘ “Why American ambulance rides are so expensive” (source of the image at the top).
And for a more straightforward, but somewhat more “radical” prescription than McDonough’s, see: “Universal Health Coverage Could Save $1 Trillion and 114,000 Lives Every Year, Yale Study Projects,” from the Yale School of Public Health: “A single-payer universal health care system could cover every American, save more than 100,000 lives a year, and still cost $1 trillion less than the system it would replace…”
Finally: this is the third (R)D in a row that focuses on (some of) the consequences of the unholy infection of government by business, largely in the U.S. (though, of course, we can see the phenomenon all over the world). The focus shifts with tomorrow’s post. But before we go, Dylan Riley‘s pithy diagnosis of “the chaotic obscenity of our current moment”: “The Thesis of Political Capitalism.”
* Dr. Martin Luther King, Jr.
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As we actually make America healthy again, we might recall that it was on this date in 1793 that prominent Philadelphia physician (and Declaration of Independence signatory) Benjamin Rush alerted the city’s mayor that an epidemic of mosquito-borne yellow fever was fast emerging.
In the summer of that year, refugees from a yellow fever epidemic in the Caribbean fled to Philadelphia. Within weeks, people throughout the city were experiencing symptoms. By the middle of October, around 100 people were dying from the virus daily. Caring for the victims so strained public services that the local city government collapsed. Philadelphia was also the seat of the United States government at the time, but federal authorities simply evacuated the city in the face of the raging epidemic. Eventually, a cold front eliminated Philadelphia’s mosquito population, and the death toll fell to 20 per day by late October. By the time the epidemic ended, roughly 5,000 people had died.
Today, a vaccine prevents yellow fever in much of the world, though thousands of unvaccinated people still die every year from the disease.

“Sometimes this high-tech world calls for low-tech solutions”*…
Our human war against infectious microbes has escalated. As bioscience has produced a stream of anti-bacterial and anti-fungal treatments, the continuously-evolving micro-organisms they target evolve in ways to protect themselves… and so our antibiotics become less effective.
This antibiotic resistance is estimated to result in more than 2.8 million infections from antibiotic-resistant bacteria, and more than 35,000 people die as a result. Antibiotic resistance adds $20 billion in excess direct healthcare costs each year in the US. Additional costs to society for lost productivity could be as high as $35 billion a year. All of this is driven in some measure by over-prescription (the CDC reckons that over 25% of antibiotics prescribed in US outpatient settings are unnecessary)– but the evolutionary dynamics of our microbial “enemies” being what they are, the problem would be material in any case.
So effective non-antibiotic treatments are especially valuable. Ian Ingram reports on one of the latest..
The FDA cleared medical-grade Australian sheep blowfly (Lucilia cuprina) larvae in what maker Cuprina Holdings believes marks the first debridement product to use this particular species.
Dubbed Medifly Maggots, the product [pictured above] is indicated for removing dead or infected tissue from non-healing necrotic skin and soft tissue wounds — such as pressure or neuropathic foot ulcers — and non-healing traumatic or post-surgical wounds.
A healthcare worker is required to oversee the application of the prescription maggot product, which was cleared based on demonstration of equivalence to the previously cleared medical-grade green bottle blowfly larvae — Lucilia sericata (Medical Maggots).
“Maggot debridement therapy has earned its place in modern wound care, and adding a second FDA-cleared species strengthens the entire field,” Ronald Sherman, MD, the company’s medical and scientific director, said in a statement.
“Lucilia cuprina has a meaningful international track record,” and the new clearance “gives clinicians and their patients more flexibility in how this therapy is delivered,” added Sherman, who has worked on the development of medical-grade maggots for decades and was instrumental in getting the first product cleared by the FDA in 2004.
According to recent estimates, anywhere from 1-2% of people in developed countries have chronic wounds, which are associated with greater risks of limb amputation and mortality.
Maggots, long used for clearing dead or non-healing tissue before the invention of antibiotics, can spare antibiotics and have also been associated with a lower risk of lower-limb amputation in diabetics with non-healing lesions…
As poet A. R. Ammons wrote (in “Catalyst“): “Honor the maggot, supreme catalyst.”
“New Type of Maggot Cleared by FDA as Medical Treatment,” from @medpagetoday.com.
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As we rethink remedies, we might spare a thought for Alice Stewart; she died on this date in 2002. A physician and epidemiologist, she specialized in social medicine and the effects of radiation on health. Starting in WW II, she investigated the health effects of exposure to TNT in ammunitions factories, of carbon tetrachloride, and a prevalence of tuberculosis among shoe industry workers.
In the 1950s, Stewart led a pioneering study of x-rays (especially the pre-natal x-rays of expectant mothers) as a cause of childhood cancer. Her results were initially regarded as unsound, but were eventually accepted worldwide; the use of medical x-rays during pregnancy and early childhood was curtailed as a result– though it took around two and a half decades.
And after a visit to the U.S. in 1974, Stewart consulted on a major investigation of the health of workers in the nuclear industry there: she examined the sickness records of employees in the Hanford (WA) plutonium production plant and found a far higher incidence of radiation-induced ill health than was noted in official studies (produced by the nuclear industry).
Stewart was awarded the Right Livelihood Award in 1986 “for bringing to light in the face of official opposition the real dangers of low-level radiation.” In 1997 she was invited to become the first Chair of the European Committee on Radiation Risk.
“What’s in a name?”
Antidepressant use is on the rise in the U.S.– and with it, the proliferation of new mood-management drug names. At the same time, the Tech Right’s fascination with The Lord of the Rings, has occasioned a flood of company and product names drawn from that fantasy series. It can be very confusing, as a new game from the folks at Vercel demonstrates. Can you tell if a name is an antidressant drug or a Tolkien character?
* Shakespeare, Romeo and Juliet (Act II, Scene II)
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As we navigate nomenclature, we might recall that it was on this date in 1941 that first injection of penicillin into a patient was administered by physician Charles Fletcher at Radcliffe Infirmary in Oxford, England.
In 1928, Alexander Fleming had discovered the anitbacterial properties of the Penicillium mold. But he had little luck convincing his medical colleagues of its value: penicillin was so difficult to isolate that its development as a drug seemed impossible. After Fletcher’s experiment and others– all of which showed promise, but “failed” when the doctors ran out of penicillin– Fleming used the hospital’s entire supply of penicillin to cure a patient of an infection of the nervous system (streptococcal meningitis) which would otherwise have been fatal. Having established medical efficacy, the doctors were able to convince labs in the U.K and the U.S. to pursue large-scale fermentation of the mold and refinments in its medical form. By June 1942, just enough US penicillin was available to treat ten patients. But with the U.S. entry into World War II, the War Production Board undertook to make penicillin available to fighting forces across the conflict. By June, 1945, over 646 billion units per year were being produced.

“In the natural world, anything that is colored so brightly must be some kind of serious evolutionary badass”*…
There are an estimated 10 quintillion (10,000,000,000,000,000,000) individual insects alive on earth today; they’ve been around for over 350 million years and ihabit nearly every environment, from deserts to snowy mountains. Their total biomass is massive, estimated to be around 70 times more than all humans combined. Often considered pests, only about 3% of species are harmful to humans; the vast majority are crucial for pollination, decomposition, and as food sources for other animals. (More insect data.)
“Loren” (and here) is a microbiologist fascinated by bugs– and ready to share…
I am incredibly fond of insects. They’re small and usually pretty fast, so it’s rewarding to successfully capture a photo of one. from 2017 to 2023, I was fairly consistent about chasing down bugs and sharing the photos on instagram, but sticking them all in a square grid can only do so much for me (or you). Here, I want to have a little more fun with my photos, and share other bug-related things that I like. There’s a lot! I am not an entomologist, merely a bug fan, so this page in its current state skews more towards the entertaining than the informative, but who knows what it may turn into. Right now there’s an entomology textbook sitting on my coffee table, and plenty of time to read it while the bugs overwinter…
Browse and learn: “The Bug Zone,” via Matt Muir (@mattmuir.bsky.social) and his always-illuminating Web Curios (@curiobot.bsky.social).
* Neal Stephenson, Cryptonomicon
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As we creep and crawl, we might spare a thought for a man concerned with “bugs” of a different sort, Joseph Lister (1st Baron Lister, OM, PC, FRS, FRCSE, FRCPGlas, FRCS); he died on this date in 1912. A surgeon, medical scientist, and experimental pathologist, he was a pioneer of antiseptic surgery and preventive healthcare. Just as John Hunter revolutionised the science of surgery, Lister’s revolutionized the craft of surgery.
Lister researched the role of inflammation and tissue perfusion in the healing of wounds, and advanced diagnostic science by analysing specimens using microscopes. But his biggest contributions were a function of his application of Louis Pasteur‘s then-novel germ theory. Lister introduced carbolic acid (modern-day phenol) as a steriliser for surgical instruments, patients’ skins, sutures, surgeons’ hands, and wards, promoting the principle of antiseptics. And he devised strategies to increase the chances of survival after surgery by reducing post-operative infections (e.g., segragating post-op patients from pre-op patients who had germ-riddled wounds).
“The vast majority of terrestrial species are in fact microbes, and scientists have only begun scratching the surface of the microbial realm. It is entirely possible that examples of life as we don’t know it have so far been overlooked.”*…
Not only do we continue to find surprising new forms of microbial life, some of them challenge our very defintion of “life.” Alice Sun reports…
Scientists recently discovered a microbe with one of the tiniest genomes on Earth. More surprising, the creature is almost entirely dependent on its host: Its genes don’t support any of the functions of metabolism, one of the key processes of life. As such, it challenges fundamental notions of what it means to be a living organism. The discovery was “pure serendipity,” says Takuro Nakayama, an evolutionary microbiologist at the University of Tsukuba in Japan. Takayama wanted to study the many microbes that live within a single-celled marine dinoflagellate, Citharistes regius, a kind of plankton. But when he and his colleagues sequenced the genes of this microbial community, they kept turning up tiny, odd chunks of DNA.
It turns out that these DNA chunks belong to some unusual archaea—a branch on the tree of life populated by single-celled microbes that can often survive in extreme environments. (Archaea are similar to bacteria, but distinct in their structure, genetics, and metabolism.)
Nakayama and his colleagues proposed the name Sukunaarchaeum mirabile for the newly-discovered microbe: Sukunaarchaeum after the Japanese dwarf deity Sukuna-biko-na, and mirabile for marvelous. At only 238,000 base pairs, the number of genes in the DNA of Sukunaarchaeum is smaller than that of any other known archaea. The scientists described their finding in a bioRxiv preprint earlier this year.
So how did Sukunaarchaeum end up with such a strikingly tiny genome? Over the course of evolution, genetic instructions for life often become increasingly complex. But evolution can also go in the other direction, leading to greater simplicity in the genome. This so-called genomic reduction, where organisms end up with fewer genes than their ancestors, is typically observed in the domains of bacteria and archaea. What struck Nakayama and his colleagues about Sukunaarchaeum was the extent of reduction and specialization in its genes.
With its stripped down genome, Sukunaarchaeum appears to be completely dependent on its host, C. regius, for essential energy and nutrients. “It likely cannot produce its own cellular building blocks,” notes Nakayama. “No previously discovered microbe has shown such an extreme degree of metabolic dependence.”
Sukunaarchaeum seems to almost inhabit a new category of life, suspended somewhere between archaea and virus. It is like viruses—which aren’t typically considered to be “alive”—in that it has a tiny genome and is totally dependent on its host for metabolism. But unlike a virus, Sukunaarchaeum has its own ribosomes, cellular structures that synthesize proteins, and it can replicate itself without the help of a host.
To get a sense of just how unusual Sukunaarchaeum is, the researchers decided to scan the oceans for potential relatives. They analyzed environmental genetic sequence data from marine environments all over the world, focusing on spots where C. regius is known to live. Using a database called the Tara Oceans project, they discovered a vast array of sequences that are comparable to that of Sukunaarchaeum, which they hypothesize could represent a new, deeply branching archaeal lineage.
For Nakayama, this additional finding suggests that many more microbes that challenge the definition of life may be out there, living in what Nakayama calls “microbial dark matter,” or microbes that can’t be cultivated in the lab. “The extreme, virus-like lifestyle we hypothesize for Sukunaarchaeum is a perfect example of the surprising outcomes found in this ‘natural laboratory of evolution,’” he says.
Mart Krupovic, a virologist and microbiologist at Institut Pasteur in France who wasn’t involved in the study, called the finding “remarkable.” Krupovic has studied giant viruses that, like Sukunaarchaeum, defy categorization. These giant viruses have evolved larger and more complex genomes that include some of the genes for DNA translation, a characteristic thought to be reserved for cellular life. “I think that is fascinating,” says Krupovic, “how little we still know about the world which surrounds us.”…
How did Sukunaarchaeum end up with such a strikingly tiny genome? “A Rogue New Life Form,” from @alicesunreports.bsky.social in @nautil.us.
See also; “Candidatus Sukunaarchaeum Mirabile Is A Novel Archaeon With An Unprecedentedly Small Genome” (source of the image at the top).
The BioRxiv preprint is here.
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As we look again at “living,” we might spare a thought for Robert Huebner; he died on this date in 1998. A physician and virologist, his research into viruses, their causes, and treatment led to his breakthrough insights into the connections between viruses and cancer, which have led to new treatments. His hypothesized oncogene was discovered to be a trigger for normal cells turning cancerous.








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