“It is a most extraordinary thing, but I never read a patent medicine advertisement without being impelled to the conclusion that I am suffering from the particular disease therein dealt with in its most virulent form”*…

We Americans spend over $60 Billion a year on dietary supplements and herbal remedies; to the extent that the market is regulated here in the U.S. it is (essentially exclusively) by the FDA– which treats the category as “food,” not “medicine” and “oversees” the industry/market very lightly. Indeed, while the extent of fraud in the supplement/remedy market (ineffective, mislabeled, or dangerous products) is estimated to be in the billions of dollars per year, the introduction to the FDA’s data base of “Health Fraud Products” reads:
This list includes unapproved products that have been subject to FDA health fraud related violations. These products have been cited in warning letters, online advisory letters, recalls, public notifications, and press announcements for issues varying from products marketed as dietary supplements claiming to cure, mitigate, treat or prevent disease, to the use of undeclared ingredients or new dietary ingredients.
This list only includes a small fraction of the potentially hazardous products marketed to consumers online and in retail establishments. Even if a product is not included in this list, consumers should exercise caution before using certain products…
That said, over half of us make those choices based on health and wellness information from social media influencers or podcasts… and too often these days, even the ostensibly qualified pitch-people are being faked by AI.
As Matthew Wills reminds us, we’ve been here before…
Never more than seventeen thousand people, the Shakers are today best remembered for their handsome furniture. In their own time they were renowned for their homemade medicinal remedies. They might have had a dubious reputation for their outlandish dancing, celibacy, gender equality, and for believing that their founder, “Mother” Ann Lee, was a manifestation of Christ’s Second Coming, but their guarantee of purity in their botanical products was generally accepted as given.
So much so that as Shaker communities dwindled through the nineteenth century, others wanted the cachet of their name in the patent medicine world. Amid all the fakery and flimflam of the pre-regulated drug market, the Shaker brand was the best.
It was worth stealing, and defending.
The Shakers, or more properly the United Society of Believers in Christ’s Second Appearing, arrived in North America from England in 1774. They established their first communes in New York and New England, then farther into the continent as the European frontier expanded. Kentucky, Ohio, Indiana, Georgia, and Florida also boasted Shaker outposts, mostly shorter-lived than the original ones.
At first, Shakers funded their separation from the “world” by selling furniture and housewares to non-Shakers. But as the number of Shakers dwindled and America’s industrial capacity increased, Shakers typically turned to selling seeds, simples [here], and botanically-based remedies. These were easier to produce, and, imbued with the Shaker reputation for purity, were as good as gold.
Medical historian J. Worth Estes quotes an 1881 almanac advertising Shaker remedies on the basic principles of Shakerism:
innocence, temperance, virgin purity, love, peace, justice, holiness, goodness, and truth. The almanac further explained that Shakers are “just and honest in all [their] dealings with mankind,” and that they “eschew every species of falsehood: lying, deceit and hypocrisy.” Such statements helped “guarantee” the purity and high quality of Shaker-made drugs in the nineteenth century struggle for the American drug market.
Shakers provided ingredients for “worldly” producers, and, in some cases, they even provided start-up capital for non-Shaker manufacturers. The A.J. White company of New York, New York, made Shaker Extract of Roots and Mother Seigel’s Curative Syrup with Shaker-sourced botanicals and capital. This remedy was advertised as “a cure for impurities of the blood” and “a cure for dyspepsia and liver complaints.” A.J. White’s company successfully expanded overseas, and when he died in 1898, his English branch bought out his American branch; in various guises the company existed until 1957, when it was purchased by Smith, Kline & French, whose successor entity is today the world’s tenth largest pharmaceutical company.
In the 1880s, Smith Bros. & Co. of Montreal started producing a product called Shakers’ Blood Syrup. This had a label similar to A.J. White’s Shaker Extract, except it said “Cures completely scrofula, cancer, rheumatism, catarrh, ulcers & skin & blood diseases.” The Shakers of New Lebanon, New York, sued for patent infringement and Smith Bros. agreed to stop pirating the Shaker name.
Shakers also produced their own remedies on their communes. Corbett’s Syrup of Sarsaparilla, for instance, was made in Canterbury, New Hampshire for about half a century until 1896. In 1886, it was one of the few Shaker products to be awarded a U.S. patent. Promoted as “a blood purifier and therefore, by implication, as a panacea,” it was made of “an aqueous mixture of sarsaparilla root, pipsissewa, yellow dock root, dandelion, thoroughwort, black cohosh, elder flowers, Epsom salts (magnesium sulfate), juniper berries, blue gentian, pokeweed root, sugar and alcohol.” At some point potassium iodide was added to “ensure the remedy’s ‘purity.’”
Estes provides a checklist of some 80 other proprietary medicines made in Shaker communities. The names are marvelous: Brother Barnabas Hinckley’s Compound Concentrated Syrup of Bitter Bugle, Eclectic Live Pills, Larus Eye Water, Vegetable Family Pills, Young Shakers’ Grand Catholicon. As Estes notes, more than a few of these products had active ingredients that were cathartic or purgative, a fact rarely noted on labels. Cathartics are generally defined as working faster than laxatives.
After the Food and Drug Act of 1906, products like the 75% alcohol (sanitizer strength!) Norwood’s Tincture of Veratrum Viride, made by non-Shakers with Shaker-sourced botanical ingredients, had to be labeled “Poison” on their instructions for use. Patent medicines, and the Shakers, didn’t survive the twentieth century…
Amid the fraud and flimflam of early drug markets, Shakers stood for purity, creating a brand others were eager to exploit: “A Trusted Name in a Dubious Drug Market” from @jstordaily.bsky.social.
* Jerome K. Jerome, Three Men in a Boat
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As we hear history rhyme, we might recall that it was on this date in 1626 that Peter Minuit, the new director of “New Netherland” for the Dutch West India Company, in what we now know as Manhattan, “purchased” the island from the the Canarsee tribe of Native Americans for a parcel of goods worth 60 guilders: roughly $24 dollars at the time, now just over $1,000.
In the event, Native Americans in the area were unfamiliar with the European notions and definitions of ownership rights. As they understood it, water, air and land could not be traded. So scholars are convinced that both parties probably went home with totally different interpretations of the sales agreement. In any case, the Carnarsees were likely happy to take payment in any meaningful amount pertaining to land that was mostly controlled by their rivals, the Weckquaesgeeks.

1626 letter from Pieter Schaghen (a colleague of Minuit) reporting the purchase of Manhattan for 60 guilders [source]
“Turkey: A large bird whose flesh, when eaten on certain religious anniversaries has the peculiar property of attesting piety and gratitude”*…
Your correspondent is hitting the road, so (Roughly) Daily will be in hiatus for ten days ro so. Regular service should resume on (or about) May 24…
Tal Lavin devotes the latest installment of The Sword and the Sandwich, the wonderful newsletter he co-authors with David Swanson, to the quintessentially-American fowl, the turkey…
There are very few occasions in life in which someone gets to choose their own name: confirmation, conversion, or, in my case, transition from female to male. Out of all the names in the world, I chose my own; I wanted to pick something that would allow me to present as my male self, that would erase confusion, that would say something essential about me. Choosing your own name is not to be taken lightly.
In the case of the turkey—that busty bird whose thinly-sliced meat is a ubiquitous filler for club sandos, Thanksgiving-leftover feasts and deli lunch-hour specials—the ability to choose its own name might have been a mercy, and avoided a tremendous amount of confusion. The etymological journey of why a turkey is called a turkey makes the fraught rite of transgender name-choosing seem like a cake walk (or bird strut).
The turkey, meleagris gallopavo, is a big galumphing bird indigenous to the Americas, famous for its huge breast, commanding carriage, and bland but abundant meat. In English, it is named after Turkey, which is a country across an entire ocean from its native stomping grounds. In Turkish, the language of Turkey, a turkey is called a hindi, which means “from India.” In Hindi, the language of India, a turkey is called a टर्की (Ṭarkī). In Slovak and Albanian, its name means “chicken from overseas.” In Scandinavian languages and Dutch, it’s named for Calicut, a major trading post along India’s Malabar Coast. In Welsh, it’s twrci. In Polish, Russian and Ukrainian, it’s indyuk, indyk or indeyka—Indian bird.
In other words, languages across the entire world are eager to praise (or blame) the wrong country for this entirely American bird. And they can’t even agree on what wrong country to attribute it to. Linguists and historians have put their heads together on why this is, and it seems to come down to a fowl case of mistaken identity.
What’s undoubtedly central to this geographical misunderstanding is the role the Ottoman Empire played in trade to Europe around the period of the Columbian Exchange…
Read on the rest of the fascinating story: “Turkey,” from @swordsjew.bsky.social.
* Ambrose Bierce, The Devil’s Dictionary
###
As we gobble, we might recall that it was on this date in 1607 that a group of 104 colonists from England arrived in what we now know as Virginia and established the first permanent English colony in America. They named the settlement Jamestown in honor of King James I.
We might also recall that we have this group (as it grew)– not the New England pilgrims– to thank for Thanksgiving.
The first documented English Thanksgiving in North America happened in Virginia in 1619, one year before the Pilgrims even arrived at Plymouth Rock. This first Thanksgiving lasted “10, 15 minutes,” according to Graham Woodlief, the president of the Virginia Thanksgiving Festival. No Native Americans were invited, no women were present, and there’s scant evidence of turkeys or yams.

We might also note that it was on this date in 1968 that Frank Zappa released his debut solo album, Lumpy Gravy on MGM’s Verve Records label (an early version of the album had been issued by Capitol Records on 4-track cartridge in August 1967).
“Sex and death are the only things that can interest a serious mind”*…
As Greg Woolf observed, “The Epic of Gilgamesh is one of the earliest examples of what is sometimes termed a “Mirror of Princes,” a book that illustrates the conduct of both bad and good rulers, and makes clear the difference between them.”
Nicolas Liney reviews a new verse translation of the 4,000-year-old text by Simon Armitage and considers its remarkable power, its extraordinary history, and its profound relevance to our moment…
There are two stories of Gilgamesh, the ancient Mesopotamian epic written in the second millennium BCE. First, there’s the story of Gilgamesh himself, the semidivine king of Uruk. He is 11 cubits tall and four cubits from nipple to nipple (roughly 16 by six feet). He is hyperactive and priapic. He is not a good ruler. The gods create the wild Enkidu out of clay to keep him in check. The pair clash mightily, and then become inseparable. Restless and hungry for glory, they journey to the Forest of Cedar to defeat the monster Humbaba. Then they slay the Bull of Heaven sent by Ishtar, the god of sex and war whose advances Gilgamesh rejects. The gods deem that Enkidu must die, and so he does, slowly and unheroically. Gilgamesh watches over Enkidu’s body until a maggot falls from his nostril, a fantastically intense image that drives home death’s finality.
At this point, the register of the poem shifts, and Gilgamesh’s triumphs are replaced by sorrow and an overwhelming awareness of his own mortality. Alone and anguished, he journeys to the underworld to visit Uta-napishti, the immortalized survivor of a cataclysmic flood, intent on unlocking the secret to eternal life. Inevitably, he is disappointed and returns to Uruk. Gilgamesh is an epic about power, about self-knowledge, about passionate companionship and the unquenchable pain of its loss. Fundamentally, it is an epic about death. Rilke labeled it “das Epos der Todesfurcht”—the epic of the fear of death—and this is what gave it its vital appeal: “It concerns me,” he confessed. “Thousands of years later death is no less bewildering to humankind,” the poet Simon Armitage says in the introduction to his new translation of the epic; “there is no more relatable subject.”
The second story of Gilgamesh is about the text itself, one of the world’s oldest surviving long-form poems. Like Homeric epic, its roots are most likely oral, and questions of authorship are futile. The earliest version was a Sumerian cycle of five poems from around 2100 BCE, probably part of a larger group of stories about the heroic dynasty of Uruk. Sumerian eventually died out, and the five episodes were replaced by one unified version in Akkadian. This was recorded in cuneiform script, often carved in clay tablets, and spread throughout Mesopotamia and the Levant. Sometime between 1300 and 1000 CE, a man called Sin-leqi-unninni created a heavily revised edition organized into 11 “tablets”—referred to now as the Standard Version—which was copied widely and included in the great library of Ashurbanipal, the Assyrian king, built in Nineveh in the seventh century.
And then … silence. By the new millennium, Akkadian was a defunct language, and Uruk and Nineveh were in ruins. As far as we know, Gilgamesh was not translated into other writing systems, so when cuneiform fell out of use, the epic seemed to go with it. For centuries it slept, until the Library of Ashurbanipal was discovered by Austen Henry Layard and Hormuzd Rassam in 1850, and what documents could be recovered were transported to the British Museum. Cuneiform was eventually deciphered, and in 1872, George Smith, an assistant curator working on the archive, came across a fragment of the epic describing a great flood—similar to the one in the Book of Genesis,but in a work significantly older than the Bible. This was too much for Smith, who began stripping his clothes off in excitement: “I am the first man to read that after more than two thousand years of oblivion.”
Critics like to say that Gilgamesh is both incredibly old and refreshingly young. Its sheer age staggers—for comparison, just try to imagine a current novel being rediscovered in the year 5120 CE. As a quasi-historical figure, Gilgamesh was considered by Babylonians to be even older: the Sumerian King List,a chronographic record,hyperbolically places his reign in 7800 BCE. Within the world of the epic itself, time reaches back further still: when Gilgamesh meets Uta-napishti, the Noah-type figure who survived the flood long before Gilgamesh, even he can speak of an “ancient city,” Shuruppak, on the banks of the Euphrates. The epic constantly forces us into these dizzying loops of deep time, forces us both to drastically exceed the limits of our brief lifespan and to be persistently reminded of them.
But Gilgamesh’s comparatively recent reentry into the modern imagination makes it feel fresh, not overburdened by centuries of interpretation and adaptation, like Homer or Virgil, and firmly outside Western literary traditions. There is no first looking into Chapman’s Gilgamesh.This can be dangerous for translators and adapters: there’s an urge to treat the epic like a blank canvas, to make it say something relevant to contemporary concerns, which can strip it of its strangeness and also cut it loose from its Iraqi heritage. But the subject matter of Gilgamesh also seems undeniably contemporary: how could a story about ecological destruction, poor leaders, and misogynist alphas not concern us here and now?…
Eminently worth reading in full. A classic which has survived, against all odds, and what it offers us today: “The Epic of the Fear of Death” from @lareviewofbooks.bsky.social.
* William Butler Yeats
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As we reach back, we might recall that it was on this date in 2004 that the discovery of what was (and is) believed to be the world’s oldest seat of learning (dating from 295 BCE), the Library of Alexandria, was announced by Zahi Hawass, president of Egypt’s Supreme Council of Antiquities during a conference at the University of California. A Polish-Egyptian team had uncovered 13 lecture halls featuring an elevated podium for the lecturer. Such a complex of lecture halls had never before been found on any Mediterranean Greco-Roman site. Alexandria may be regarded as the birthplace of western science, where Euclid discovered the rules of geometry, Eratosthenes measured the diameter of the Earth and Ptolemy wrote the Almagest, the most influential scientific book about the nature of the Universe for 1,500 years.
See also: “Oldest University Unearthed in Egypt“
“The clearest way into the Universe is through a forest”*…

Dillon Osleger explains that, while the future of Western forests depends on professional pinecone collectors, they’re slowly being starved out of existence…
High in the crown of a giant sequoia, the world becomes a cathedral of green and amber, hushed but for the creak of ancient wood and the sharp, rhythmic snap of cones being pulled from boughs. Dan Keeley, 31, moved around with a practiced, fluid economy, suspended by thin lines of high-tensile rope 200 feet above the ground on the western edge of California’s Sequoia National Park. To his left, the sequoia’s cinnamon-colored bark provided a steady presence as he leaned out over the negative space between branches.
“There is a lot of trust that goes into this work,” Keeley said, speaking over the wind. He eyed a cluster of green, egg-sized cones. “Trust in the trees, predominantly, but also trust in the system — that I’m being sent to the right trees, at the right time, and for the right reason, not all of which are always the case.”
Keeley, a lean, tanned former rock climber and arborist, is what some in the forestry industry call a pinecone cowboy, a freelance contractor hired to harvest the genetic future of Western forests. He climbs trees of important or threatened species to collect ripe cones for seeds intended to be used for reforestation.
Keeley is part of a specialized workforce that’s become the primary resistance against the rapid erasure of a Western landscape. As megafires — fueled by climate change and a century of heavy-handed forest management and fire suppression — incinerate millions of acres in the West, natural regeneration is failing. Cones from serotinous species, which open their scales and drop their seeds in response to low-intensity wildfires on the forest floor, are now incinerated in increasingly common crown fires — high-intensity blazes that leap into the canopy. Meanwhile, other species’ seeds, dropped into the soil by wind and animals like squirrels and birds, are choked underneath layers of ash or outcompeted by invasive shrubs. The future of a relationship between trees and wildfires that has existed for 350 million years now rests on the shoulders of rope-suspended climbers who collect the trees’ cones one 45-liter bag at a time…
[The work, which dates back to the 1930s, is both arduous and precise; the workers, dedicated. But, as Osleger explains, a number of forces– main among them, Federal budget cuts, have taken a huge toll on the effort…]
… The result is an annual reforestation shortfall that is compounding and transforming entire ecosystems. The Forest Service produces 30 million to 50 million seedlings a year, according to American Forests, a mere fraction of the 120-million annual seedling goal the REPLANT Act established. Roughly 80% of those seedlings will survive, while it takes about 220 trees to reforest each burned acre. Altogether, the agency meets just 6% of its post-wildfire planting needs annually, according to its 2022 Reforestation Strategy Report.
And that’s just on Forest Service land: Wildfires on both public and private lands have affected, on average, 7.8 million acres a year over the last decade, according to the National Interagency Fire Center. In California alone, current seedling production and planting rates mean that it would take 15 to 20 years to reforest what has already been lost, while each additional fire “puts us further behind,” said Kuldeep Singh, operations manager of seed production for CAL FIRE. While the Forest Service considers a tract reforested after seedlings survive their first five years, research says that a functioning ecosystem like the one the fire destroyed won’t return for several decades.
When a forest fails to regenerate, either because it wasn’t replanted or because new seedlings didn’t survive, it often becomes scrub-land, in a permanent ecological shift known as type conversion. The new brush-based ecosystem creates a more flammable fuel bed that resists the forest’s return, effectively locking the land into a cycle of fire and scrub. In areas like South Lake Tahoe, California, for example, fields of 8-foot-tall manzanita and buckbrush now dominate hundreds of acres where conifers once stood. In Oregon, Washington, Idaho, Wyoming and throughout the Southwest, Forest Service research says that high-severity burn areas — which are difficult to regenerate regardless of human intervention — are increasingly repopulated by invasive grasses or the flowering plants called Brassicaceae, which store less carbon and prevent conifers from taking root. This process is permanently altering the hydrology, fire cycle and carbon-sequestration capacity of the West…
More– and more photos– at: “The plight of the pinecone cowboy,” from @highcountrynews.org.
Pair with: “Make Your Own Micro Forest” (“The Miyawaki method of reforestation inserts small, densely packed wild acreage into urban environs. It’s proving wildly successful.”)
* John Muir
###
As we treasure trees, we might recall that it was on this date in 1910 that Glacier National Park in northwestern Montana was established. The park encompasses more than 1 million acres and includes parts of two mountain ranges (sub-ranges of the Rocky Mountains), more than 130 named lakes, more than 1,000 different species of trees and plants, and hundreds of species of animals. Its pristine ecosystem is the centerpiece of what has been referred to as the “Crown of the Continent Ecosystem,” a region of protected land encompassing 16,000 square miles.
The park’s predominantly coniferous forest is home to various species of trees such as the Engelmann spruce, Douglas fir, subalpine fir, limber pine and western larch, which is a deciduous conifer, producing cones but losing its needles each fall.

“Gambling is a tax on ignorance”*…
And as Einstein observed, “two things are infinite: the universe and human stupidity; and I’m not sure about the universe.”
Gambling– and related specualtive investments– have always been, for the vast majority of punters, a sucker’s bet. But, as Paul Kedrosky explains, the growing prevalence of AI and the emergence of prediction markets have amplified that painful reality…
The return skew in prediction markets’ returns is startling. It is partly a function of their nature, but also of vibe-coding script kiddies attacking every market anomaly as quickly as it arises. Check a recent WSJ article for examples.
The same dynamic is now spreading across retail-dominated markets. A driver is how AI lowers the cost of systematic exploitation and exploration to near zero. What used to require infrastructure, data pipelines, and bearded quants is now accessible via off-the-shelf models, APIs, and loosely stitched “agent” workflows doing … stuff that even their users don’t fully understand.
The result isn’t democratization of returns. It is wider participation, of a sort, alongside the rapid re-concentration of profits. A small subset of users—those willing to iterate fastest, monitor continuously, and deploy capital programmatically—capture gains, with everyone else just liquidity.
They scrape sentiment, parse new information, and reprice positions in seconds, compressing the half-life of mispricings. That doesn’t eliminate inefficiency, but changes who harvests it. The edge shifts from insight to speed, coverage, and execution discipline—areas where even modest automation compounds quickly, and edges disappear overnight.
Prediction markets are simply the cleanest expression of this trend because they combine thin liquidity, discrete outcomes, and high retail participation. But the same pattern is visible in options flow, single-stock volatility events, and even online poker, which AI increasingly dominates.
As AI tools continue to scale, expect this to get worse: a small cohort running semi-automated strategies extracting semi-consistent edge, and a much larger base supplying them returns. Under the pressure of AI prevalance, markets don’t flatten, the return gradient steepens to a cliff…
Fewer and fewer winners take more and more of the pot. The mechanics of concentration: “AI is Eating Markets” from @paulkedrosky.com.
* Warren Buffett
###
As we contemplate concentration, we might note that today is Mother’s Day. As noted yesterday, the observance became official on that date in 1914. But the quest to honor moms began a good bit earlier. On this date in 1908, Anna Jarvis held a memorial for her mother at St. Andrew’s Methodist Church in Grafton, West Virginia, the location of the International Mother’s Day Shrine. But her quest to create Mother’s Day had begun three years earlier when her mother Ann, a lifelong activist, died.
Ann had tried to start a “Mother’s Remembrance Day” in the mid-19th century. On her passing, Anna enlisted the support of retailer extraordinaire John Wanamaker, who knew a merchandising opportunity when he saw one, and who hosted the first Mother’s Day ceremonies in his Philadelphia emporium’s auditorium. In 1912, Anna trademarked the phrases “second Sunday in May” and “Mother’s Day”, and created the Mother’s Day International Association. By 1914, she and Wanamaker had built sufficient support in Congress to score the Congressional Resolution noted yesterday. (President Wilson, who was by current accounts uninterested in the move– distracted as he was by the beginnings of his ultimately unsuccessful effort to keep the U.S. out of the troubles in Europe that became World War I– nonetheless knew better than to take a stand against moms.)






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