Posts Tagged ‘medicine’
“Foul cankering rust the hidden treasure frets, but gold that’s put to use more gold begets.”*…
The scientific literature is vast. No individual human can fully know all the published research findings, even within a single field of science. As Ulkar Aghayeva explains, regardless of how much time a scientist spends reading the literature, there’ll always be what the information scientist Don Swanson called ‘undiscovered public knowledge’: knowledge that exists and is published somewhere, but still remains largely unknown.
Some scientific papers receive very little attention after their publication – some, indeed, receive no attention whatsoever. Others, though, can languish with few citations for years or decades, but are eventually rediscovered and become highly cited. These are the so-called ‘sleeping beauties’ of science.
The reasons for their hibernation vary. Sometimes it is because contemporaneous scientists lack the tools or practical technology to test the idea. Other times, the scientific community does not understand or appreciate what has been discovered, perhaps because of a lack of theory. Yet other times it’s a more sublunary reason: the paper is simply published somewhere obscure and it never makes its way to the right readers.
What can sleeping beauties tell us about how science works? How do we rediscover information the scientific body of knowledge already contains but that is not widely known? Is it possible that, if we could understand sleeping beauties in a more systematic way, we might be able to accelerate scientific progress?
Sleeping beauties are more common than you might expect.
The term sleeping beauties was coined by Anthony van Raan, a researcher in quantitative studies of science, in 2004. In his study, he identified sleeping beauties between 1980 and 2000 based on three criteria: first, the length of their ‘sleep’ during which they received few if any citations. Second, the depth of that sleep – the average number of citations during the sleeping period. And third, the intensity of their awakening – the number of citations that came in the four years after the sleeping period ended. Equipped with (somewhat arbitrarily chosen) thresholds for these criteria, van Raan identified sleeping beauties at a rate of about 0.01 percent of all published papers in a given year.
Later studies hinted that sleeping beauties are even more common than that. A systematic study in 2015, using data from 384,649 papers published in American Physical Society journals, along with 22,379,244 papers from the search engine Web of Science, found a wide, continuous range of delayed recognition of papers in all scientific fields. This increases the estimate of the percentage of sleeping beauties at least 100-fold compared to van Raan’s.
Many of those papers became highly influential many decades after their publication – far longer than the typical time windows for measuring citation impact. For example, Herbert Freundlich’s paper ‘Concerning Adsorption in Solutions’ (though its original title is in German) was published in 1907, but began being regularly cited in the early 2000s due to its relevance to new water purification technologies. William Hummers and Richard Offeman’s ‘Preparation of Graphitic Oxide’, published in 1958, also didn’t ‘awaken’ until the 2000s: in this case because it was very relevant to the creation of the soon-to-be Nobel Prize–winning material graphene…
Indeed, one of the most famous physics papers, Albert Einstein, Boris Podolsky, and Nathan Rosen (EPR)’s ‘Can Quantum-Mechanical Description of Physical Reality Be Considered Complete?’ (1935) is a classic example of a sleeping beauty…
More examples, and explanation of why they slumber, and thoughts on how to awaken them sooner: “Waking up science’s sleeping beauties,” from @ulkar_aghayeva in @WorksInProgMag.
[Image above: source]
* Shakespeare, “Venus and Adonis”
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As we dwell on discovery, we might send healing birthday greetings to a woman whose scientific work thankfully rarely napped, Gertrude Elion; she was born on this date in 1918. A pharmacologist, she shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design (focused on understanding the target of the drug rather than simply using trial-and-error) in the development of new drugs. Her work led to the creation of the anti-retroviral drug AZT, which was the first drug widely used against AIDS. Her well-known and widely deployed creations also include the first immunosuppressive drug, azathioprine, used to fight rejection in organ transplants, the first successful antiviral drug, acyclovir (ACV), used in the treatment of herpes infection, and a number of drugs used in cancer treatment.
“Just because you’re paranoid doesn’t mean they aren’t after you”*…
The wages of anxiety…
A large Swedish study has uncovered a paradox about people diagnosed with an excessive fear of serious illness: They tend to die earlier than people who aren’t hypervigilant about health concerns.
Hypochondriasis, now called illness anxiety disorder, is a rare condition with symptoms that go beyond average health worries. People with the disorder are unable to shake their fears despite normal physical exams and lab tests. Some may change doctors repeatedly. Others may avoid medical care…
The researchers found that people with the diagnosis have an increased risk of death from both natural and unnatural causes, particularly suicide. Chronic stress and its impact on the body could explain some of the difference, the authors wrote…
“In hypochondria paradox, Swedish study finds a higher death rate in those who fear serious illness,” by @CarlaKJohnson in @AP.
* Joseph Heller, Catch-22
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As we stew over self-fulfilling prophecies, we might recall that it was on this date in 2021 that Paul E. Marek, et al. published a paper in Scientific Reports reporting the discovery of the first millipede species that lived up to its name. Although called millipedes, meaning 1000 legs, never before had a species been found with truly that many legs.
In fact, the new species, Eumillipes persephone has 1306 legs. This diminutive animal has a greatly elongated, thread-like body (0.95 mm wide, 95.7 mm long) with 330 segments, a cone-shaped head with enormous antennae, and a beak for feeding. It was found 60 m below ground in a drill hole created for mineral exploration in Western Australia. Living as a troglobite, it lacks eyes and pigmentation.
“Without mysteries, life would be very dull indeed”*…
Colonoscopies are a right of passage into late middle-age. One dreads getting a “surprise”– the finding of a polyp. But one doesn’t anticipate other kinds of surprise…
Doctors in Missouri were baffled to spot a fly inside a man’s intestines during a routine colon screening.
Images taken during the colonoscopy and published in the American Journal of Gastroenterology show the intact fly inside the man’s colon.
Matthew Bechtold, the chief of Gastroenterology at the University of Missouri, told The Independent that he had prodded the fly and confirmed it was dead.
The 63-year-old patient told doctors that he had only consumed clear liquids the day before the procedure and had no idea how the fly had gotten into his colon.
He said he had eaten pizza and lettuce for dinner two days before the procedure but did not remember a fly being in his food.
The finding was described as “a very rare colonoscopy finding and mystery on how the intact fly found its way to the transverse colon.”…
Wonder never cease: “Bizarre Discovery of Intact Housefly in Man’s Intestines Shocks Doctors,” in @ScienceAlert, via @BoingBoing.
* Charles de Lint
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As we investigate intrusive insects, we might spare a thought for Seymour Benzer; he died on this date in 2007. A physicist, molecular biologist, and behavioral geneticist, he developed a method for determining the detailed structure of viral genes, did much to elucidate the nature of genetic anomalies (called nonsense mutations), and identified mutant genes useful for studying Creutzfeld-Jacob (CJ) disease and other human brain degenerative disorders… all using the ubiquitous cousin of the housefly– the fruit fly– as a research subject.
Benzer was awarded the National Medal of Science (in 1982), among many other major awards and recognitions.
“In all chaos there is a cosmos, in all disorder a secret order”*…
Between 1617 and 1621 the English physician and polymath Robert Fludd published his masterpiece Utriusque Cosmi . . . Historia, a two-volume work packed with over sixty intricate engravings. Urszula Szulakowska looks at the philosophical and theological ideas behind the extraordinary images found in the first volume, an exploration of the macrocosm of the universe and spiritual realm…
Robert Fludd was a respected English physician (of Welsh origins) employed at the court of King James I of England. He was a prolific writer of vast, multi-volume encyclopaedias in which he discussed a universal range of topics from magical practices — such as alchemy, astrology, kabbalism, and fortune-telling — to radical theological thinking concerning the interrelation of God with the natural and human worlds. However, he also proudly displayed his grasp of practical knowledge, such as mechanics, architecture, military fortifications, armaments, military manoeuvres, hydrology, musical theory and musical instruments, mathematics, geometry, optics, and the art of drawing, as well as chemistry and medicine. Fludd used the common metaphor for the arts as being the “ape of Nature”, a microcosmic form of how the universe itself functioned.
Fludd’s most famous work is the History of the Two Worlds (Utriusque Cosmi . . . Historia, 1617-21) published in two volumes by Theodore de Bry in Oppenheim. The two worlds under discussion are those of the Microcosm of human life on earth and the Macrocosm of the universe (which included the spiritual realm of the Divine).
Fludd himself was a staunch member of the Anglican Church. He was educated in the medical profession at St. John’s College in Oxford. At the turn of the seventeenth century, he set out for an extended period of travel on the continent. He spent a winter with some Jesuits, a Roman Catholic order deeply opposed to Protestantism who, nevertheless, tutored Fludd on magical practices. Fludd, however, always claimed to have worked out the theological and magical systems in his first volume of the Utriusque Cosmi . . . Historia (1617) during his undergraduate days at Oxford. In this work Fludd devised a lavishly illustrated cosmology based on the chemical theory of Paracelsus, in which the materials of the universe were separated out of chaos by God who acted in the manner of a laboratory alchemist…
All of Fludd’s treatises were lavishly illustrated with extraordinary engravings, unique in their form and subject matter, which have the visionary quality of a genuine spiritual seer and which exerted an influence on his contemporary occultists such as Michael Maier, Jacob Boehme, and Johannes Mylius. Fludd himself designed these images and they were engraved by the artisans employed at his publishers. (Some of his own original drawings still exist for the first volume of the Utriusque Cosmi . . . Historia, 1617)…
Read on for more explanation and many more mesmerizing images. A 17th century “theory of everything”: “Robert Fludd and His Images of The Divine,” in @PublicDomainRev.
* Carl Jung
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As we think holistically, we might recall that it was on this date in 1859 that our perspective was shifted in a different kind of way: Charles Darwin published The Origin of the Species. Actually, on that day he published On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life; the title was shortened to the one we know with the sixth edition in 1872.
“It is not the germs we need worry about. It is our inner terrain.”*…
Background becomes foreground: Jean-Laurent Casanova on how we might better think about infectious diseases…
In 1955, René Dubos famously expressed his “second thoughts on the germ theory”, attributing infectious diseases to various “changing circumstances” that weaken the host by unknown mechanisms. He rightly stressed that only a small minority of individuals infected by almost any microbe develop clinical disease. Intriguingly, though, he did not mention the abundant and elegant findings reported from 1905 onward that unambiguously pointed to host genetic determinants of infection outcome in plants and animals, including human inborn errors of immunity. Diverse findings over the next 50 y[ears] corroborated and extended these earlier genetic and immunological observations that René Dubos had neglected. Meanwhile, the sequential advent of immunosuppression- and HIV–driven immunodeficiencies unexpectedly provided a mechanistic basis for his own views. Collectively, these two lines of evidence support a host theory of infectious diseases, with inherited and acquired immunodeficiencies as the key determinants of severe infection outcome, relegating the germ to an environmental trigger that reveals an underlying and preexisting cause of disease and death…
The full essay: “From second thoughts on the germ theory to a full-blown host theory,” from @PNASNews.
Pair with: “The World Is Toxic. Welcome to the Metabolic Era,” from @k_pendergrast in @WIRED.
* Louis Pasteur (who was clearly already having second thoughts)
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As we contemplate the clinical, we might sending healing birthday greetings to Charles Mayo; he was born on this date in 1865. A medical doctor (surgeon) and philanthropist, he co-founded the Mayo Clinic and it’s supporting/governing body, the Mayo Foundation. Within Mayo’s lifetime, it registered one million patients. As of today, Mayo Clinic has ranked number one in the United States for seven consecutive years in U.S. News & World Report‘s Best Hospitals Honor Roll, maintaining a position at or near the top for more than 35 years.
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