Posts Tagged ‘mutation’
“It is sad to go to pieces like this but we all have to do it”*…
Still, some species “do it” differently than others…
It is well known that somatic mutations — mutations in our body’s genetic code that accumulate over time — can cause cancer, but their broader role in ageing is less clear.
Now a team of researchers have measured the somatic mutation rates of a range of mammals and discovered a striking correlation between mutation rate and lifespan. Lending evidence to the theory that somatic mutations are a cause of ageing rather than a result of it…
Ageing is linked to accumulated mutations: “The lifespan secret: why giraffes live longer than ferrets,” from @Nature.
* Mark Twain, on aging
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As we grow old gracefully, we might send carefully-deduced birthday greetings to William Ian Beardmore (WIB) Beveridge; he was born on this date in 1908. A veterinarian who served as director of the Institute of Animal Pathology at Cambridge, he identified the origin of the Great Influenza (the Spanish Flu pandemic, 1918-19)– a strain of swine flu.
“How is it that you keep mutating and can still be the same virus?”*…
A common plant has yielded insights that question a fundamental assumption in biology– more specifically, an assumption about the mechanism of natural selection…
A simple roadside weed may hold the key to understanding and predicting DNA mutation, according to new research from University of California, Davis, and the Max Planck Institute for Developmental Biology in Germany.
The findings, published today in the journal Nature, radically change our understanding of evolution and could one day help researchers breed better crops or even help humans fight cancer.
Mutations occur when DNA is damaged and left unrepaired, creating a new variation. The scientists wanted to know if mutation was purely random or something deeper. What they found was unexpected.
“We always thought of mutation as basically random across the genome,” said Grey Monroe, an assistant professor in the UC Davis Department of Plant Sciences who is lead author on the paper. “It turns out that mutation is very non-random and it’s non-random in a way that benefits the plant. It’s a totally new way of thinking about mutation.”
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Knowing why some regions of the genome mutate more than others could help breeders who rely on genetic variation to develop better crops. Scientists could also use the information to better predict or develop new treatments for diseases like cancer that are caused by mutation.
“Our discoveries yield a more complete account of the forces driving patterns of natural variation; they should inspire new avenues of theoretical and practical research on the role of mutation in evolution,” the paper concludes.
Evolutionary theory revised? A new study challenges the received wisdom that that DNA mutations are random. Read the underlying paper here.
* Chuck Palahniuk, Invisible Monsters
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As we contemplate change, we might send micro-biological birthday greetings to Ruth Sager; she was born on this date in 1918. A geneticist, she had two careers in science.
In the 1950s and 1960s, she pioneered the field of cytoplasmic genetics by discovering transmission of genetic traits through chloroplast DNA, the first known example of genetics not involving the cell nucleus. The academic community did not acknowledge the significance of her contribution until after the second wave of feminism in the 1970s.
Then, in the early 1970s, she moved into cancer genetics (with a specific focus on breast cancer); she proposed and investigated the roles of tumor suppressor genes.
“I like it when a flower or a little tuft of grass grows through a crack in the concrete. It’s so f#@kin’ heroic.”*…
From dilapidated power plants, abandoned medical facilities, and amusement parks left in rusted ruin, the compelling scenes that French photographer Jonathan Jimenez, aka Jonk (previously), captures are evidence of nature’s endurance and power to reclaim spaces transformed by people. Now compiled in a new book titled Naturalia II, 221 images shot across 17 countries frame the thriving vegetation that crawls across chipped concrete and architecture in unruly masses.
This succeeding volume is a follow-up to Jonk’s first book by the same name and focuses on the ways the ecological crisis has evolved during the last three years. He explains the impetus for the book in a statement:
On the one hand, the situation has deteriorated even further with yet another species becoming extinct every single day. Global warming continues and has caused repeated natural catastrophes: floods, fires, droughts, etc. On the other hand, our collective awareness has widely increased. We are still a long way from the commitment needed to really change things, but we are heading in the right direction. Millions of initiatives have already emerged, and I hope that my photos and the message contained within them can play a small part in the collective challenge facing us all…
More at “Nature Resurges to Overtake Abandoned Architecture in a New Book of Photos by Jonk” and at his site.
On an apposite note: “Forest the size of France regrown worldwide over 20 years, study finds.”
* George Carlin
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As we inspect the inexorable, we might spare a thought for Hugo Marie de Vries; he died on this date in 1935. A botanist, he introduced the experimental study of organic evolution– and was, thus, was one of the first geneticists. His rediscovery in 1900 (simultaneously with the botanists Carl Correns and Erich Tschermak von Seysenegg) of Gregor Mendel’s principles of heredity and his theory of biological mutation, though considerably different from a modern understanding of the phenomenon, resolved ambiguous concepts concerning the nature of variation of species that, until then, had precluded the universal acceptance and active investigation of Charles Darwin’s system of organic evolution.
He suggested the concept of genes and introduced the term “mutation”, and developed a mutation theory of evolution.
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