Posts Tagged ‘molecular biology’
“In the attempt to make scientific discoveries, every problem is an opportunity and the more difficult the problem, the greater will be the importance of its solution”*…
(Roughly) Daily is headed into its traditional Holiday hibernation; regular service will begin again very early in the New Year.
It seems appropriate (especially given the travails of this past year) to end the year on a positive and optimistic note, with a post celebrating an extraordinary accomplishment– Science magazine‘s (thus, the AAAS‘) “Breakthrough of the Year” for 2021…
In his 1972 Nobel Prize acceptance speech, American biochemist Christian Anfinsen laid out a vision: One day it would be possible, he said, to predict the 3D structure of any protein merely from its sequence of amino acid building blocks. With hundreds of thousands of proteins in the human body alone, such an advance would have vast applications, offering insights into basic biology and revealing promising new drug targets. Now, after nearly 50 years, researchers have shown that artificial intelligence (AI)-driven software can churn out accurate protein structures by the thousands—an advance that realizes Anfinsen’s dream and is Science’s 2021 Breakthrough of the Year.
AI-powered predictions show proteins finding their shapes: the full story: “Protein structures for all.”
And read Nature‘s profile of the scientist behind the breakthrough: “John Jumper: Protein predictor.”
* E. O. Wilson
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As we celebrate science, we might send well-connected birthday greetings to Robert Elliot Kahn; he was born on this date in 1938. An electrical engineer and computer scientist, he and his co-creator, Vint Cerf, first proposed the Transmission Control Protocol (TCP) and the Internet Protocol (IP), the fundamental communication protocols at the heart of the Internet. Later, he and Vint, along with fellow computer scientists Lawrence Roberts, Paul Baran, and Leonard Kleinrock, built the ARPANET, the first network to successfully link computers around the country.
Kahn has won the Turing Award, the National Medal of Technology, and the Presidential Medal Of Freedom, among many, many other awards and honors.
Emergent-cy…
Scripps Research Institute biologist Gerald Joyce (pictured above) and his colleague Tracey Lincoln have built an “immortal molecule.” They have synthesized RNA enzymes – ribonucleic acid enzymes also known as ribozymes – that replicate themselves without the help of any proteins or other cellular components. And since these simple nucleic acids can act as catalysts, the process can continue indefinitely.
As Cosmos reports,
The ultimate goal is to create genetic systems that behave like life, and are for all intents “life” as we know it, but arose without using biological systems.
“The aim is to create systems that have inventive capabilities, that can develop novel solutions to challenges posed by the environment. But that we don’t have yet,” [Joyce] said.
“What we do have is a self-sustained chemical system that undergoes Darwinian evolution. They are synthetic genetic systems, and they are evolving. But they’re not living because they don’t yet show the capacity to invent a whole cloth of functions. The idea is to give them enough information wherewithal [genetic building blocks] so they can start inventing their own solutions rather than just optimizing existing solutions,” he added.
Joyce said it was not practical to synthesize the more complex DNA-based life we know from scratch; it’s too complex and probably beyond today’s science. But it is conceivable to start with a much more basic form of life-like molecules based on RNA, and use evolution to build on them.
Many scientists believe that early life was based on RNA and predated the arrival of life based on deoxyribonucleic acid (DNA) and proteins. RNA, which can both store information like DNA as well as act as an enzyme like proteins, may have supported pre-cellular life.
A leading proponent of this so-called “RNA world” hypothesis, Joyce believes that RNA-based catalysis and information storage may have been the first step in the evolution of cellular life.
Read the whole story here.
As we search our closets for those chemistry sets, we might celebrate the emergence of a technology that took on a life of its own and changed… well, everything: this date in 1455 is the traditionally-given date of the publication of the Gutenberg Bible, the first Western book printed from movable type. The Jikji— the world’s oldest known extant movable metal type printed book– was published in Korea in 1377. Bi Sheng created the first known moveable type– out of wood– in China in 1040.
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