“I don’t do drugs. I am drugs.”*…
Drug companies have a problem: they are finding it ever harder to get painkillers through clinical trials. But this isn’t necessarily because the drugs are getting worse. An extensive analysis of trial data has found that responses to sham treatments have become stronger over time, making it harder to prove a drug’s advantage over placebo…
Bad, good, or simply confusing news? Decide for yourself at Nature.
* Salvador Dalí
As we take the red pill, we might recall that it was on this date in 1814 that London suffered “The Great Beer Flood Disaster” when the metal bands on an immense vat at Meux’s Horse Shoe Brewery snapped, releasing a tidal wave of 3,555 barrels of Porter (571 tons– more than 1 million pints), which swept away the brewery walls, flooded nearby basements, and collapsed several adjacent tenements. While there were reports of over twenty fatalities resulting from poisoning by the porter fumes or alcohol coma, it appears that the death toll was 8, and those from the destruction caused by the huge wave of beer in the structures surrounding the brewery.
(The U.S. had its own vat mishap in 1919, when a Boston molasses plant suffered similarly-burst bands, creating a heavy wave of molasses moving at a speed of an estimated 35 mph; it killed 21 and injured 150.)